BIOCHEMICAL AND HISTOCHEMICAL CHANGES IN RATS EXPOSED TO CRUDE VENOM OF SYNANCEIA VERRUCOSA

This study aimed to determine the effect of crude venom of Synanceia verrucosa on some biochemical and
histochemical changes in rats' The median lethal dose (LD 50 ) of crude venom of Synanceia verrucosa was 351.3
g\kg body weights. Some behavioral characters were observed as quick and irregular movement with the quick
breathing, distinct relatively fast heart beats parlays which finally leachable from nose and internal bleeding and
death. The results revealed that an elevation of glucose cholesterol, aspartate and alanine transaminases, alkaline
phosphates enzymes' trigrycerides, urea and createnine within 30-90 min. with significant differences (p<0'05)
after injection by the toxin, while, the level of triglyceride was decreased gradually' Histochemical studies were
carried out on river and kidney of treated rats. Histochemical sections of the treated liver by the crude venom of
the Synanceia verrucosa showed leucocytes infiltration, swelling of hepatocytes and enlarging in size of their
nuclei and chromatin elements. Treated kidney by the crude venom of synanceia verrucosa showed that, the
Bowman's capsule and epithelium cells of cortex and medulla of the kidney are shrunken. Some tubular kidney
cortex showed a dilatation while they were atrophy' In addition, parenchymatous degeneration of cells of renal
tubules, vaculation and in filtration between the proximal tubules were observed