In vitro CYTOTOXIC EFFECT OF ZIRCONIUM OXIDE NANOPARTICLE AND ITS ANTIBACTERIAL ACTIVITY AGAINST ORAL PATHOGENS

Introduction: From last decay nanotechnology is playing advance in various fields in the research field. Nanoparticles are the most required scientific tool that acts as a bridge between atomic or molecular or atomic structure with bulk material. They have unique properties like magnetic, optical and excellent in catalytic. In this study we are going to see the In vitro cytotoxic effect of zirconium oxide nanoparticle and its antibacterial activity against oral pathogens.

Materials and Methods: Zirconium oxide nanoparticles are synthesized by taking Azadirachta indica and aloe vera plant extract and nanoparticle powder is prepared. And then in vitro cytotoxic effect is done by using brine shrimp lethal assay.And then antibacterial activity test is done against the oral pathogens.

Results: Zirconium oxide nanoparticles are toxic if the concentration is increased but in lower concentrations the function is best. The action against the oral pathogens. In small concentrations S. aureus showed an 8mm zone of inhibition when the concentration increased S. mutans showed 11mm zone of inhibition.

Conclusion: The zirconium oxide nanoparticles can be used as antibacterial agents against the oral pathogens in small quantities. Thus in future nanoparticles are going to role the developing countries in various fields of medicine.