HISTOPATHOLOGICAL STUDY OF ORAL MAGNESIUM (MG) ADMINISTRATION AGAINST CHRONIC CADMIUM (CD) TOXICITY IN WISTAR RATS ON (LIVER, KIDNEY, SPLEEN AND BRAIN)

Toxicity by cadmium induced damages and histopathological changes in liver, kidneys, spleen and brain of Wistar rats. This research aimed at investigating the potential protective effects of magnesium on the histoarchitectural integrity of tissues and organs.

Forty male Wistar rats were randomly divided into 4 groups during 3 months: Control group received water, Cd group water and oral administration at dose 15 mg/Kg of CdCl2, (Cd+Mg) group water and oral administration at doses (15 mg / kg of CdCl2+ 10 mg/kg of MgCl2) and Mg group water and oral administration (10 mg/kg of MgCl2).

A histopahtological study was carried to show the beneficial effect of magnesium treatment against chronic cadmium toxicity.

Administration of cadmium for 3 months led to apparent histological abnormalities, damages and alterations to liver, kidney, spleen and brain. A supplementation of magnesium showed significant histological improvements and markedly reduced tissue damage when compared with Cadmium Group.

Results of this study demonstrate that the oral administration of magnesium in rats exposure to cadmium chronic toxicity ameliorated the histopathological changes observed in the liver, kidney, spleen and brain with no observable alteration in the histoarchitecture in the organs of the magnesium-supplemented rats.