Comparative Study of Common Antioxidants and Dithiooxamide in Lipid Autoxidation

Since the 1980s, the authors have been researching anti-ageing, oxidation, and antioxidants. They discovered that lipids are some of the most common raw materials in foods, cosmetics, and the human body, and that this would be a good area to investigate autoxidation, whether to prevent spoilage or to slow ageing.

The scientists chose a few lipids for an autoxidation investigation and put them up against typical pro-oxidants and antioxidants, as well as a potential antioxidant candidate, along with a short-term toxicity assessment. The lipids were exposed to increased temperatures in the presence of several pro-oxidants, some typical commercial antioxidants, and the antioxidant candidate, as well as a control. Following that, the authors analyzed the lipids for oxidation by-products and conducted a short-term toxicity investigation. Lipids that have been kept in iron, copper, or other heavy metals, or that have been contaminated with such metals, are prone to autoxidation. Aluminium appears to provide lipids an induction period and does not speed up autoxidation like other metals. When compared to antioxidants like vitamin E, BHA, BHT, and PG, the antioxidant candidate dithiooxamide appears to be a capable antioxidant with no short-term toxicity in a limited sample study, which was far below the LDLo and LD50 conducted on rats and mice using dithioxamide in other later published research. The findings suggest that lipids should steer clear of iron, copper, and other heavy metals, and that the antioxidant candidate dithiooxamide, in small doses, could be effective for external lipid applications.