Editorial: Interventional strategies for enhancing quality of life and health span in older adults, volume II

Aging is a natural and complex process that starts at conception and finishes at death. Several phenomena occur in individuals across the lifespan that can influence human health and wellbeing (Li et al., 2021). Some changes are related to heredity, nutritional quality and quantity, levels of physical activity, and actions that contribute to mental health, however, other factors are still unknown or poorly understood. Consequently, it is relevant to attempt to stimulate researchers to explore interventional strategies for enhancing quality of life in older adults and discuss diseases that might compromise older individuals.

Normal aging is associated with the accumulation of deleterious and undesirable changes that occur in the body's tissues, cells, and molecules, that can lead to an increased risk of co-occurring diseases and premature mortality. In general, most strategies to lengthen life expectancy have mainly been based in the need for effective interventions that might help offset the deleterious effects of aging. However, the costs associated with aging and a longer life expectancy have still increased over the decades due to the nature and severity of chronic age-related diseases. As a result, there is an urgent need to offer effective pharmacological and non-pharmacological interventions to improve quality of life, wellbeing, and independence in older adults. Therefore, the aim of this special issue is to summarize the most recent and relevant approaches permitting to understand and resume the most important parameters related to the aging process.

The current Research Topic includes nine contributions: two reviews (one systematic review and meta-analysis, one systematic reviews) and seven original articles. These findings were divided into the following sections: stroke, cognition impairment, frailty, and translational research about neuroinflammation and behavior in old rats.